![]() J Pharm Pharm Sci 16(1):99–114Ībraham AS, Sonnenblick M, Eini M, Shemesh O, Batt AP (1980) The effect of chromium on established atherosclerotic plaques in rabbits. KeywordsĪbdollahi M, Farshchi A, Nikfar S et al (2013) Effect of chromium on glucose and lipid profiles in patients with type 2 diabetes a meta-analysis review of randomized trials. Studies have investigated the effects of chromium supplementation on diabetes, obesity, and dyslipidemia, but the results are still incipient for the development of guidelines recommending supplementation in risk groups. Trivalent chromium demonstrated an important role in gene expression, mainly in hepatocytes, insulin activity, and adiposity. This mineral is also present in nutritional supplements featuring various structures such as chromium picolinate, chromium histidinate, chromium chloride, and chromium nicotinate. ![]() Therefore, some studies indicate that chromium-deficient diets may favor insulin resistance, with consequent development of type 2 diabetes. Chromium is related to changes that encompass carbohydrate and lipid metabolism. Along with other metallic ions, its transport is related to the performance of transferrin, and there may be competition for sites that bind to iron and other minerals. Despite the low molecular weight, there is a small absorption capacity of chromium and its absorption occurs in the intestine by passive transport. Studies show that during the various life stages, there are different needs of ingestion of this mineral. Although it is present in several foods in small quantities, there is still no recommended average requirement. Chromium is a micronutrient found in several oxidation states, being trivalent chromium and hexavalent chromium the most prevalent.
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